| Title |
Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts
|
|---|---|
| Published in |
Cell, September 2016
|
| DOI | 10.1016/j.cell.2016.08.020 |
| Pubmed ID | |
| Authors |
Brigida Gallone, Jan Steensels, Troels Prahl, Leah Soriaga, Veerle Saels, Beatriz Herrera-Malaver, Adriaan Merlevede, Miguel Roncoroni, Karin Voordeckers, Loren Miraglia, Clotilde Teiling, Brian Steffy, Maryann Taylor, Ariel Schwartz, Toby Richardson, Christopher White, Guy Baele, Steven Maere, Kevin J. Verstrepen |
| Abstract |
Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates from. Here, we present the genomes and phenomes of 157 industrial Saccharomyces cerevisiae yeasts. Our analyses reveal that today's industrial yeasts can be divided into five sublineages that are genetically and phenotypically separated from wild strains and originate from only a few ancestors through complex patterns of domestication and local divergence. Large-scale phenotyping and genome analysis further show strong industry-specific selection for stress tolerance, sugar utilization, and flavor production, while the sexual cycle and other phenotypes related to survival in nature show decay, particularly in beer yeasts. Together, these results shed light on the origins, evolutionary history, and phenotypic diversity of industrial yeasts and provide a resource for further selection of superior strains. PAPERCLIP. |
X Demographics
The data shown below were collected from the profiles of 502 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 140 | 28% |
| United Kingdom | 43 | 9% |
| Canada | 20 | 4% |
| Germany | 13 | 3% |
| Japan | 12 | 2% |
| Australia | 10 | 2% |
| France | 7 | 1% |
| Ireland | 6 | 1% |
| Belgium | 6 | 1% |
| Other | 58 | 12% |
| Unknown | 187 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 286 | 57% |
| Scientists | 197 | 39% |
| Science communicators (journalists, bloggers, editors) | 15 | 3% |
| Practitioners (doctors, other healthcare professionals) | 4 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | <1% |
| France | 4 | <1% |
| Germany | 3 | <1% |
| Spain | 3 | <1% |
| Netherlands | 2 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| South Africa | 1 | <1% |
| Other | 10 | <1% |
| Unknown | 1179 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 206 | 17% |
| Researcher | 190 | 16% |
| Student > Master | 190 | 16% |
| Student > Bachelor | 186 | 15% |
| Student > Doctoral Student | 40 | 3% |
| Other | 166 | 14% |
| Unknown | 238 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 403 | 33% |
| Biochemistry, Genetics and Molecular Biology | 360 | 30% |
| Immunology and Microbiology | 40 | 3% |
| Chemistry | 34 | 3% |
| Engineering | 25 | 2% |
| Other | 93 | 8% |
| Unknown | 261 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 644. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2024.
All research outputs
#34,755
of 25,845,895 outputs
Outputs from Cell
#249
of 17,301 outputs
Outputs of similar age
#672
of 349,855 outputs
Outputs of similar age from Cell
#4
of 178 outputs
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