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Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Overview of attention for article published in American Journal of Human Genetics, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 5,136)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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68 Dimensions

Readers on

mendeley
151 Mendeley
citeulike
3 CiteULike
Title
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility
Published in
American Journal of Human Genetics, May 2016
DOI 10.1016/j.ajhg.2016.03.008
Pubmed ID
Authors

Hamdi Mbarek, Stacy Steinberg, Dale R. Nyholt, Scott D. Gordon, Michael B. Miller, Allan F. McRae, Jouke Jan Hottenga, Felix R. Day, Gonneke Willemsen, Eco J. de Geus, Gareth E. Davies, Hilary C. Martin, Brenda W. Penninx, Rick Jansen, Kerrie McAloney, Jacqueline M. Vink, Jaakko Kaprio, Robert Plomin, Tim D. Spector, Patrik K. Magnusson, Bruno Reversade, R. Alan Harris, Kjersti Aagaard, Ragnar P. Kristjansson, Isleifur Olafsson, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, William G. Iacono, Cornelis B. Lambalk, Grant W. Montgomery, Matt McGue, Ken K. Ong, John R.B. Perry, Nicholas G. Martin, Hreinn Stefánsson, Kari Stefánsson, Dorret I. Boomsma

Abstract

Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10(-9), and rs17293443 in SMAD3, p = 1.57 × 10(-8)) and replicated (p = 3 × 10(-3) and p = 1.44 × 10(-4), respectively). Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score (PRS) for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland (p = 0.001). A higher PRS was also associated with having children (p = 0.01), greater lifetime parity (p = 0.03), and earlier age at first child (p = 0.02). Allele rs11031006-G was associated with higher serum FSH levels, earlier age at menarche, earlier age at first child, higher lifetime parity, lower PCOS risk, and earlier age at menopause. Conversely, rs17293443-C was associated with later age at last child. We identified robust genetic risk variants for DZ twinning: one near FSHB and a second within SMAD3, the product of which plays an important role in gonadal responsiveness to FSH. These loci contribute to crucial aspects of reproductive capacity and health.

Twitter Demographics

The data shown below were collected from the profiles of 83 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 <1%
Netherlands 1 <1%
United States 1 <1%
Luxembourg 1 <1%
Unknown 147 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 15%
Researcher 21 14%
Student > Bachelor 20 13%
Student > Master 13 9%
Professor 12 8%
Other 40 26%
Unknown 22 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 25%
Medicine and Dentistry 24 16%
Biochemistry, Genetics and Molecular Biology 22 15%
Psychology 12 8%
Social Sciences 6 4%
Other 22 15%
Unknown 27 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 765. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2021.
All research outputs
#14,217
of 18,368,557 outputs
Outputs from American Journal of Human Genetics
#9
of 5,136 outputs
Outputs of similar age
#353
of 271,819 outputs
Outputs of similar age from American Journal of Human Genetics
#3
of 60 outputs
Altmetric has tracked 18,368,557 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,136 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.