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| Title |
Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma
|
|---|---|
| Published in |
Cancer Cell, April 2016
|
| DOI | 10.1016/j.ccell.2016.03.012 |
| Pubmed ID | |
| Authors |
Wei Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, Yuchao Gu, Ken Herrmann, Dazy Johnson, Xiangming Ding, Kiwook Hwang, Jungwoo Kim, Jian Zhou, Yapeng Su, Xinmin Li, Bruno Bonetti, Rajesh Chopra, C. David James, Webster K. Cavenee, Timothy F. Cloughesy, Paul S. Mischel, James R. Heath, Beatrice Gini |
| Abstract |
Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy resistance, including in the highly lethal brain cancer glioblastoma (GBM). We performed single-cell phosphoproteomics on a patient-derived in vivo GBM model of mTOR kinase inhibitor resistance and coupled it to an analytical approach for detecting changes in signaling coordination. Alterations in the protein signaling coordination were resolved as early as 2.5 days after treatment, anticipating drug resistance long before it was clinically manifest. Combination therapies were identified that resulted in complete and sustained tumor suppression in vivo. This approach may identify actionable alterations in signal coordination that underlie adaptive resistance, which can be suppressed through combination drug therapy, including non-obvious drug combinations. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 32% |
| United Kingdom | 4 | 13% |
| Italy | 2 | 6% |
| Turkey | 1 | 3% |
| Germany | 1 | 3% |
| Canada | 1 | 3% |
| Ireland | 1 | 3% |
| Mexico | 1 | 3% |
| Switzerland | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 9 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 52% |
| Scientists | 14 | 45% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 335 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Brazil | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 322 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 90 | 27% |
| Researcher | 64 | 19% |
| Student > Master | 25 | 7% |
| Student > Bachelor | 23 | 7% |
| Student > Doctoral Student | 17 | 5% |
| Other | 61 | 18% |
| Unknown | 55 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 93 | 28% |
| Agricultural and Biological Sciences | 73 | 22% |
| Medicine and Dentistry | 33 | 10% |
| Chemistry | 20 | 6% |
| Engineering | 12 | 4% |
| Other | 42 | 13% |
| Unknown | 62 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 107. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#416,749
of 26,437,155 outputs
Outputs from Cancer Cell
#256
of 3,235 outputs
Outputs of similar age
#7,223
of 316,519 outputs
Outputs of similar age from Cancer Cell
#5
of 57 outputs
Altmetric has tracked 26,437,155 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,235 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.