↓ Skip to main content

Cell Press

Article Metrics

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

Overview of attention for article published in Current Biology, March 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Citations

dimensions_citation
92 Dimensions

Readers on

mendeley
193 Mendeley
citeulike
2 CiteULike
Title
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Published in
Current Biology, March 2016
DOI 10.1016/j.cub.2015.12.071
Pubmed ID
Authors

Angus Davison, Gary S. McDowell, Jennifer M. Holden, Harriet F. Johnson, Georgios D. Koutsovoulos, M. Maureen Liu, Paco Hulpiau, Frans Van Roy, Christopher M. Wade, Ruby Banerjee, Fengtang Yang, Satoshi Chiba, John W. Davey, Daniel J. Jackson, Michael Levin, Mark L. Blaxter

Abstract

While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria [1, 2]. Here, we report that a disabling mutation in one copy of a tandemly duplicated, diaphanous-related formin is perfectly associated with symmetry breaking in the pond snail. This is supported by the observation that an anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, drug inhibition or overexpression by microinjection of formin has a chirality-randomizing effect in early (pre-cilia) embryos. Contrary to expectations based on existing models [3-5], we discovered asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry. As the formin-actin filament has been shown to be part of an asymmetry-breaking switch in vitro [6, 7], together these results are consistent with the view that animals with diverse body plans may derive their asymmetries from the same intracellular chiral elements [8].

Twitter Demographics

The data shown below were collected from the profiles of 358 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Japan 2 1%
United Kingdom 2 1%
Finland 1 <1%
Argentina 1 <1%
Belgium 1 <1%
Norway 1 <1%
Netherlands 1 <1%
Unknown 182 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 54 28%
Student > Bachelor 35 18%
Student > Ph. D. Student 33 17%
Student > Master 16 8%
Professor > Associate Professor 10 5%
Other 31 16%
Unknown 14 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 77 40%
Biochemistry, Genetics and Molecular Biology 62 32%
Neuroscience 5 3%
Physics and Astronomy 5 3%
Medicine and Dentistry 5 3%
Other 23 12%
Unknown 16 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 600. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2020.
All research outputs
#17,231
of 16,105,110 outputs
Outputs from Current Biology
#167
of 11,312 outputs
Outputs of similar age
#433
of 268,002 outputs
Outputs of similar age from Current Biology
#8
of 194 outputs
Altmetric has tracked 16,105,110 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,312 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 194 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.