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Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus

Overview of attention for article published in Cell, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

8 news outlets
2 blogs
115 tweeters
11 Facebook pages
2 Google+ users
2 Redditors
1 video uploader

Readers on

134 Mendeley
3 CiteULike
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Published in
Cell, August 2015
DOI 10.1016/j.cell.2015.07.020
Pubmed ID

Andersen, Kristian G, Shapiro, B Jesse, Matranga, Christian B, Sealfon, Rachel, Lin, Aaron E, Moses, Lina M, Folarin, Onikepe A, Goba, Augustine, Odia, Ikponmwonsa, Ehiane, Philomena E, Momoh, Mambu, England, Eleina M, Winnicki, Sarah, Branco, Luis M, Gire, Stephen K, Phelan, Eric, Tariyal, Ridhi, Tewhey, Ryan, Omoniwa, Omowunmi, Fullah, Mohammed, Fonnie, Richard, Fonnie, Mbalu, Kanneh, Lansana, Jalloh, Simbirie, Gbakie, Michael, Saffa, Sidiki, Karbo, Kandeh, Gladden, Adrianne D, Qu, James, Stremlau, Matthew, Nekoui, Mahan, Finucane, Hilary K, Tabrizi, Shervin, Vitti, Joseph J, Birren, Bruce, Fitzgerald, Michael, McCowan, Caryn, Ireland, Andrea, Berlin, Aaron M, Bochicchio, James, Tazon-Vega, Barbara, Lennon, Niall J, Ryan, Elizabeth M, Bjornson, Zach, Milner, Danny A, Lukens, Amanda K, Broodie, Nisha, Rowland, Megan, Heinrich, Megan, Akdag, Marjan, Schieffelin, John S, Levy, Danielle, Akpan, Henry, Bausch, Daniel G, Rubins, Kathleen, McCormick, Joseph B, Lander, Eric S, Günther, Stephan, Hensley, Lisa, Okogbenin, Sylvanus, , , Schaffner, Stephen F, Okokhere, Peter O, Khan, S Humarr, Grant, Donald S, Akpede, George O, Asogun, Danny A, Gnirke, Andreas, Levin, Joshua Z, Happi, Christian T, Garry, Robert F, Sabeti, Pardis C, Kristian G. Andersen, B. Jesse Shapiro, Christian B. Matranga, Rachel Sealfon, Aaron E. Lin, Lina M. Moses, Onikepe A. Folarin, Augustine Goba, Ikponmwonsa Odia, Philomena E. Ehiane, Mambu Momoh, Eleina M. England, Sarah Winnicki, Luis M. Branco, Stephen K. Gire, Eric Phelan, Ridhi Tariyal, Ryan Tewhey, Omowunmi Omoniwa, Mohammed Fullah, Richard Fonnie, Mbalu Fonnie, Lansana Kanneh, Simbirie Jalloh, Michael Gbakie, Sidiki Saffa, Kandeh Karbo, Adrianne D. Gladden, James Qu, Matthew Stremlau, Mahan Nekoui, Hilary K. Finucane, Shervin Tabrizi, Joseph J. Vitti, Bruce Birren, Michael Fitzgerald, Caryn McCowan, Andrea Ireland, Aaron M. Berlin, James Bochicchio, Barbara Tazon-Vega, Niall J. Lennon, Elizabeth M. Ryan, Zach Bjornson, Danny A. Milner, Amanda K. Lukens, Nisha Broodie, Megan Rowland, Megan Heinrich, Marjan Akdag, John S. Schieffelin, Danielle Levy, Henry Akpan, Daniel G. Bausch, Kathleen Rubins, Joseph B. McCormick, Eric S. Lander, Stephan Günther, Lisa Hensley, Sylvanus Okogbenin, Stephen F. Schaffner, Peter O. Okokhere, S. Humarr Khan, Donald S. Grant, George O. Akpede, Danny A. Asogun, Andreas Gnirke, Joshua Z. Levin, Christian T. Happi, Robert F. Garry, Pardis C. Sabeti


The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.

Twitter Demographics

The data shown below were collected from the profiles of 115 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
United States 2 1%
Spain 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
Finland 1 <1%
Japan 1 <1%
Netherlands 1 <1%
Unknown 124 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 31%
Researcher 25 19%
Student > Master 15 11%
Student > Postgraduate 13 10%
Student > Bachelor 9 7%
Other 31 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 49%
Biochemistry, Genetics and Molecular Biology 31 23%
Medicine and Dentistry 12 9%
Immunology and Microbiology 8 6%
Nursing and Health Professions 4 3%
Other 14 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 153. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
of 8,632,847 outputs
Outputs from Cell
of 9,317 outputs
Outputs of similar age
of 230,491 outputs
Outputs of similar age from Cell
of 181 outputs
Altmetric has tracked 8,632,847 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,317 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 181 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.