| Title |
Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells
|
|---|---|
| Published in |
Cell Reports, June 2015
|
| DOI | 10.1016/j.celrep.2015.05.015 |
| Pubmed ID | |
| Authors |
Jan-Philipp Mallm, Karsten Rippe |
| Abstract |
Non-coding RNAs can modulate histone modifications that, at the same time, affect transcript expression levels. Here, we dissect such a network in mouse embryonic stem cells (ESCs). It regulates the activity of the reverse transcriptase telomerase, which synthesizes telomeric repeats at the chromosome ends. We find that histone H3 serine 10 phosphorylation set by Aurora kinase B (AURKB) in ESCs during the S phase of the cell cycle at centromeric and (sub)telomeric loci promotes the expression of non-coding minor satellite RNA (cenRNA). Inhibition of AURKB induces silencing of cenRNA transcription and establishment of a repressive chromatin state with histone H3 lysine 9 trimethylation and heterochromatin protein 1 accumulation. This process results in a continuous shortening of telomeres. We further show that AURKB interacts with both telomerase and cenRNA and activates telomerase in trans. Thus, in mouse ESCs, telomere maintenance is regulated via expression of cenRNA in a cell-cycle-dependent manner. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 50% |
| France | 2 | 17% |
| Netherlands | 1 | 8% |
| Indonesia | 1 | 8% |
| Italy | 1 | 8% |
| Unknown | 1 | 8% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 58% |
| Science communicators (journalists, bloggers, editors) | 3 | 25% |
| Scientists | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 41 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 31% |
| Researcher | 9 | 21% |
| Student > Bachelor | 5 | 12% |
| Other | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 48% |
| Biochemistry, Genetics and Molecular Biology | 13 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Neuroscience | 1 | 2% |
| Unknown | 7 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2015.
All research outputs
#2,539,318
of 25,374,917 outputs
Outputs from Cell Reports
#5,471
of 12,960 outputs
Outputs of similar age
#31,682
of 281,077 outputs
Outputs of similar age from Cell Reports
#71
of 182 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,960 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
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We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.