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Interferon-γ Drives T reg Fragility to Promote Anti-tumor Immunity

Overview of attention for article published in Cell, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
66 news outlets
blogs
1 blog
twitter
121 tweeters
facebook
5 Facebook pages

Citations

dimensions_citation
236 Dimensions

Readers on

mendeley
451 Mendeley
citeulike
1 CiteULike
Title
Interferon-γ Drives T reg Fragility to Promote Anti-tumor Immunity
Published in
Cell, June 2017
DOI 10.1016/j.cell.2017.05.005
Pubmed ID
Authors

Abigail E. Overacre-Delgoffe, Maria Chikina, Rebekah E. Dadey, Hiroshi Yano, Erin A. Brunazzi, Gulidanna Shayan, William Horne, Jessica M. Moskovitz, Jay K. Kolls, Cindy Sander, Yongli Shuai, Daniel P. Normolle, John M. Kirkwood, Robert L. Ferris, Greg M. Delgoffe, Tullia C. Bruno, Creg J. Workman, Dario A.A. Vignali

Abstract

Regulatory T cells (Tregs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral Treg stability and function but is dispensable for peripheral immune tolerance. Treg-restricted Nrp1 deletion results in profound tumor resistance due to Treg functional fragility. Thus, identifying the basis for Nrp1 dependency and the key drivers of Treg fragility could help to improve immunotherapy for human cancer. We show that a high percentage of intratumoral NRP1(+) Tregs correlates with poor prognosis in melanoma and head and neck squamous cell carcinoma. Using a mouse model of melanoma where Nrp1-deficient (Nrp1(-/-)) and wild-type (Nrp1(+/+)) Tregs can be assessed in a competitive environment, we find that a high proportion of intratumoral Nrp1(-/-) Tregs produce interferon-γ (IFNγ), which drives the fragility of surrounding wild-type Tregs, boosts anti-tumor immunity, and facilitates tumor clearance. We also show that IFNγ-induced Treg fragility is required for response to anti-PD1, suggesting that cancer therapies promoting Treg fragility may be efficacious.

Twitter Demographics

The data shown below were collected from the profiles of 121 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 451 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Korea, Republic of 1 <1%
France 1 <1%
Israel 1 <1%
Denmark 1 <1%
Chile 1 <1%
Unknown 443 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 129 29%
Researcher 101 22%
Student > Master 42 9%
Other 27 6%
Student > Bachelor 26 6%
Other 70 16%
Unknown 56 12%
Readers by discipline Count As %
Immunology and Microbiology 126 28%
Agricultural and Biological Sciences 75 17%
Biochemistry, Genetics and Molecular Biology 74 16%
Medicine and Dentistry 71 16%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Other 26 6%
Unknown 70 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 588. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2021.
All research outputs
#23,153
of 18,890,258 outputs
Outputs from Cell
#199
of 15,866 outputs
Outputs of similar age
#629
of 280,316 outputs
Outputs of similar age from Cell
#7
of 136 outputs
Altmetric has tracked 18,890,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,866 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,316 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.