Report for: Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Title	Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
Published in	Cell, June 2017
DOI	10.1016/j.cell.2017.05.005
Pubmed ID	28552348
Authors	Abigail E. Overacre-Delgoffe, Maria Chikina, Rebekah E. Dadey, Hiroshi Yano, Erin A. Brunazzi, Gulidanna Shayan, William Horne, Jessica M. Moskovitz, Jay K. Kolls, Cindy Sander, Yongli Shuai, Daniel P. Normolle, John M. Kirkwood, Robert L. Ferris, Greg M. Delgoffe, Tullia C. Bruno, Creg J. Workman, Dario A.A. Vignali
Abstract	Regulatory T cells (Tregs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral Treg stability and function but is dispensable for peripheral immune tolerance. Treg-restricted Nrp1 deletion results in profound tumor resistance due to Treg functional fragility. Thus, identifying the basis for Nrp1 dependency and the key drivers of Treg fragility could help to improve immunotherapy for human cancer. We show that a high percentage of intratumoral NRP1(+) Tregs correlates with poor prognosis in melanoma and head and neck squamous cell carcinoma. Using a mouse model of melanoma where Nrp1-deficient (Nrp1(-/-)) and wild-type (Nrp1(+/+)) Tregs can be assessed in a competitive environment, we find that a high proportion of intratumoral Nrp1(-/-) Tregs produce interferon-γ (IFNγ), which drives the fragility of surrounding wild-type Tregs, boosts anti-tumor immunity, and facilitates tumor clearance. We also show that IFNγ-induced Treg fragility is required for response to anti-PD1, suggesting that cancer therapies promoting Treg fragility may be efficacious.

View on publisher site Alert me about new mentions

Twitter Demographics

The data shown below were collected from the profiles of 116 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	35	30%
United Kingdom	6	5%
Spain	5	4%
Australia	3	3%
France	2	2%
Denmark	2	2%
Canada	2	2%
Brazil	1	<1%
Mexico	1	<1%
Other	15	13%
Unknown	44	38%

Demographic breakdown

Type	Count	As %
Members of the public	81	70%
Scientists	24	21%
Practitioners (doctors, other healthcare professionals)	8	7%
Science communicators (journalists, bloggers, editors)	3	3%

Mendeley readers

The data shown below were compiled from readership statistics for 554 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	2	<1%
Chile	1	<1%
Korea, Republic of	1	<1%
France	1	<1%
Denmark	1	<1%
Israel	1	<1%
Unknown	547	99%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	152	27%
Researcher	110	20%
Student > Master	47	8%
Student > Bachelor	36	6%
Other	32	6%
Other	81	15%
Unknown	96	17%

Readers by discipline	Count	As %
Immunology and Microbiology	140	25%
Biochemistry, Genetics and Molecular Biology	93	17%
Medicine and Dentistry	78	14%
Agricultural and Biological Sciences	77	14%
Unspecified	11	2%
Other	43	8%
Unknown	112	20%

Attention Score in Context

This research output has an Altmetric Attention Score of 585. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2021.

All research outputs

#34,654

of 23,642,687 outputs

Outputs from Cell

#261

of 16,781 outputs

Outputs of similar age

#751

of 317,442 outputs

Outputs of similar age from Cell

of 136 outputs

Altmetric has tracked 23,642,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 16,781 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has done particularly well, scoring higher than 98% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,442 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.

Cell Press

Article Metrics

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

About this Attention Score

Mentioned by

Citations

Readers on

Twitter Demographics

Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context