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Biomechanics of Borrelia burgdorferi Vascular Interactions

Overview of attention for article published in Cell Reports, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
22 news outlets
blogs
1 blog
twitter
73 X users
facebook
10 Facebook pages
googleplus
5 Google+ users
video
1 YouTube creator

Citations

dimensions_citation
43 Dimensions

Readers on

mendeley
83 Mendeley
citeulike
1 CiteULike
Title
Biomechanics of Borrelia burgdorferi Vascular Interactions
Published in
Cell Reports, August 2016
DOI 10.1016/j.celrep.2016.08.013
Pubmed ID
Authors

Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty

Abstract

Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascular endothelia in blood vessels, remain unknown. Here, we show that endothelial interactions of the Lyme disease spirochete Borrelia burgdorferi under physiological shear stress mechanistically resemble selectin-dependent leukocyte rolling. Specifically, these interactions are mediated by transfer of mechanical load along a series of adhesion complexes and are stabilized by tethers and catch bond properties of the bacterial adhesin BBK32. Furthermore, we found that the forces imposed on adhesive bonds under flow may be small enough to permit active migration driven by bacterial flagellar motors. These findings provide insight into the biomechanics of bacterial-vascular interactions and demonstrate that disseminating bacteria and circulating host immune cells share widely conserved mechanisms for interacting with endothelia under physiological shear stress.

X Demographics

X Demographics

The data shown below were collected from the profiles of 73 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Sweden 1 1%
Canada 1 1%
Unknown 79 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Bachelor 13 16%
Student > Master 10 12%
Student > Ph. D. Student 9 11%
Other 8 10%
Other 8 10%
Unknown 22 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 24%
Medicine and Dentistry 11 13%
Immunology and Microbiology 7 8%
Agricultural and Biological Sciences 5 6%
Engineering 3 4%
Other 11 13%
Unknown 26 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 226. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#168,309
of 25,382,360 outputs
Outputs from Cell Reports
#212
of 12,920 outputs
Outputs of similar age
#3,319
of 350,542 outputs
Outputs of similar age from Cell Reports
#9
of 308 outputs
Altmetric has tracked 25,382,360 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,920 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 308 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.