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Biomechanics of Borrelia burgdorferi Vascular Interactions

Overview of attention for article published in Cell Reports, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
22 news outlets
blogs
1 blog
twitter
80 tweeters
facebook
8 Facebook pages
googleplus
5 Google+ users
video
1 video uploader

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
44 Mendeley
citeulike
1 CiteULike
Title
Biomechanics of Borrelia burgdorferi Vascular Interactions
Published in
Cell Reports, September 2016
DOI 10.1016/j.celrep.2016.08.013
Pubmed ID
Authors

Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty

Abstract

Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascular endothelia in blood vessels, remain unknown. Here, we show that endothelial interactions of the Lyme disease spirochete Borrelia burgdorferi under physiological shear stress mechanistically resemble selectin-dependent leukocyte rolling. Specifically, these interactions are mediated by transfer of mechanical load along a series of adhesion complexes and are stabilized by tethers and catch bond properties of the bacterial adhesin BBK32. Furthermore, we found that the forces imposed on adhesive bonds under flow may be small enough to permit active migration driven by bacterial flagellar motors. These findings provide insight into the biomechanics of bacterial-vascular interactions and demonstrate that disseminating bacteria and circulating host immune cells share widely conserved mechanisms for interacting with endothelia under physiological shear stress.

Twitter Demographics

The data shown below were collected from the profiles of 80 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
United Kingdom 1 2%
United States 1 2%
Sweden 1 2%
Canada 1 2%
Unknown 39 89%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 23%
Researcher 9 20%
Unspecified 5 11%
Other 5 11%
Student > Ph. D. Student 5 11%
Other 10 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 27%
Medicine and Dentistry 10 23%
Unspecified 7 16%
Engineering 3 7%
Agricultural and Biological Sciences 3 7%
Other 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 234. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2018.
All research outputs
#45,460
of 12,303,024 outputs
Outputs from Cell Reports
#69
of 5,549 outputs
Outputs of similar age
#2,359
of 265,057 outputs
Outputs of similar age from Cell Reports
#8
of 292 outputs
Altmetric has tracked 12,303,024 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,549 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,057 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 292 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.