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| Title |
HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing
|
|---|---|
| Published in |
Cell Reports, February 2015
|
| DOI | 10.1016/j.celrep.2015.01.038 |
| Pubmed ID | |
| Authors |
Ahuvi Yearim, Sahar Gelfman, Ronna Shayevitch, Shai Melcer, Ohad Glaich, Jan-Philipp Mallm, Malka Nissim-Rafinia, Ayelet-Hashahar S. Cohen, Karsten Rippe, Eran Meshorer, Gil Ast |
| Abstract |
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can either enhance or silence exon recognition and affects the splicing of more than 20% of alternative exons. These exons are characterized by distinct genetic and epigenetic signatures. Alternative splicing regulation of a subset of these exons can be explained by heterochromatin protein 1 (HP1), which silences or enhances exon recognition in a position-dependent manner. We constructed an experimental system using site-specific targeting of a methylated/unmethylated gene and demonstrate a direct causal relationship between DNA methylation and alternative splicing. HP1 regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form. Our results demonstrate DNA methylation's significant global influence on mRNA splicing and identify a specific mechanism of splicing regulation mediated by HP1. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 14% |
| United Kingdom | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 43% |
| Members of the public | 3 | 43% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 284 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 1% |
| United Kingdom | 2 | <1% |
| South Africa | 1 | <1% |
| Czechia | 1 | <1% |
| New Zealand | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Greece | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 271 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 25% |
| Researcher | 50 | 18% |
| Student > Bachelor | 35 | 12% |
| Student > Master | 31 | 11% |
| Professor | 12 | 4% |
| Other | 37 | 13% |
| Unknown | 48 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 100 | 35% |
| Biochemistry, Genetics and Molecular Biology | 94 | 33% |
| Neuroscience | 11 | 4% |
| Medicine and Dentistry | 10 | 4% |
| Immunology and Microbiology | 3 | 1% |
| Other | 11 | 4% |
| Unknown | 55 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2022.
All research outputs
#4,835,465
of 25,373,627 outputs
Outputs from Cell Reports
#7,983
of 12,955 outputs
Outputs of similar age
#54,672
of 269,216 outputs
Outputs of similar age from Cell Reports
#104
of 197 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,216 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.