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HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

Overview of attention for article published in Cell Reports, February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
7 tweeters
weibo
1 weibo user
wikipedia
1 Wikipedia page

Citations

dimensions_citation
129 Dimensions

Readers on

mendeley
225 Mendeley
Title
HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing
Published in
Cell Reports, February 2015
DOI 10.1016/j.celrep.2015.01.038
Pubmed ID
Authors

Ahuvi Yearim, Sahar Gelfman, Ronna Shayevitch, Shai Melcer, Ohad Glaich, Jan-Philipp Mallm, Malka Nissim-Rafinia, Ayelet-Hashahar S. Cohen, Karsten Rippe, Eran Meshorer, Gil Ast

Abstract

The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can either enhance or silence exon recognition and affects the splicing of more than 20% of alternative exons. These exons are characterized by distinct genetic and epigenetic signatures. Alternative splicing regulation of a subset of these exons can be explained by heterochromatin protein 1 (HP1), which silences or enhances exon recognition in a position-dependent manner. We constructed an experimental system using site-specific targeting of a methylated/unmethylated gene and demonstrate a direct causal relationship between DNA methylation and alternative splicing. HP1 regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form. Our results demonstrate DNA methylation's significant global influence on mRNA splicing and identify a specific mechanism of splicing regulation mediated by HP1.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 3 1%
United Kingdom 2 <1%
New Zealand 1 <1%
South Africa 1 <1%
Netherlands 1 <1%
Czechia 1 <1%
Korea, Republic of 1 <1%
Spain 1 <1%
Japan 1 <1%
Other 2 <1%
Unknown 211 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 28%
Researcher 43 19%
Student > Bachelor 29 13%
Student > Master 28 12%
Professor > Associate Professor 10 4%
Other 31 14%
Unknown 22 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 93 41%
Biochemistry, Genetics and Molecular Biology 76 34%
Medicine and Dentistry 9 4%
Neuroscience 8 4%
Immunology and Microbiology 2 <1%
Other 6 3%
Unknown 31 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2020.
All research outputs
#3,040,948
of 17,136,794 outputs
Outputs from Cell Reports
#4,848
of 8,405 outputs
Outputs of similar age
#43,325
of 221,569 outputs
Outputs of similar age from Cell Reports
#101
of 202 outputs
Altmetric has tracked 17,136,794 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,405 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,569 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 202 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.