| Title |
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
|
|---|---|
| Published in |
Trends in Genetics, September 2014
|
| DOI | 10.1016/j.tig.2014.08.004 |
| Pubmed ID | |
| Authors |
Aurélie Kapusta, Cédric Feschotte |
| Abstract |
Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important biochemical, cellular, and developmental activities is steadily growing. However, it is increasingly clear that lncRNA repertoires are subject to weak functional constraint and rapid turnover during vertebrate evolution. We discuss here some of the factors that may explain this apparent paradox, including relaxed constraint on sequence to maintain lncRNA structure/function, extensive redundancy in the regulatory circuits in which lncRNAs act, as well as adaptive and non-adaptive forces such as genetic drift. We explore the molecular mechanisms promoting the birth and rapid evolution of lncRNA genes, with an emphasis on the influence of bidirectional transcription and transposable elements, two pervasive features of vertebrate genomes. Together these properties reveal a remarkably dynamic and malleable noncoding transcriptome which may represent an important source of robustness and evolvability. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 23% |
| United Kingdom | 4 | 13% |
| France | 3 | 10% |
| Denmark | 1 | 3% |
| Canada | 1 | 3% |
| India | 1 | 3% |
| Japan | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 11 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 15 | 50% |
| Members of the public | 12 | 40% |
| Science communicators (journalists, bloggers, editors) | 3 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 380 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| France | 3 | <1% |
| Brazil | 2 | <1% |
| United States | 2 | <1% |
| Spain | 2 | <1% |
| India | 2 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 363 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 96 | 25% |
| Researcher | 81 | 21% |
| Student > Master | 43 | 11% |
| Student > Bachelor | 24 | 6% |
| Professor > Associate Professor | 20 | 5% |
| Other | 68 | 18% |
| Unknown | 48 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 170 | 45% |
| Biochemistry, Genetics and Molecular Biology | 113 | 30% |
| Medicine and Dentistry | 15 | 4% |
| Immunology and Microbiology | 8 | 2% |
| Computer Science | 5 | 1% |
| Other | 16 | 4% |
| Unknown | 53 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2022.
All research outputs
#1,278,568
of 25,373,627 outputs
Outputs from Trends in Genetics
#163
of 2,382 outputs
Outputs of similar age
#13,198
of 250,305 outputs
Outputs of similar age from Trends in Genetics
#4
of 23 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,382 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.