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HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

Overview of attention for article published in Cell Host & Microbe (Science Direct), August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
8 news outlets
twitter
7 tweeters

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
87 Mendeley
Title
HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria
Published in
Cell Host & Microbe (Science Direct), August 2014
DOI 10.1016/j.chom.2014.07.003
Pubmed ID
Authors

Ashley M. Trama, M. Anthony Moody, S. Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, Christina Stolarchuk, Richard Scearce, Andrew Foulger, Dawn J. Marshall, John F. Whitesides, Thomas L. Jeffries, Kevin Wiehe, Lynn Morris, Bronwen Lambson, Kelly Soderberg, Kwan-Ki Hwang, Georgia D. Tomaras, Nathan Vandergrift, Katherine J.L. Jackson, Krishna M. Roskin, Scott D. Boyd, Thomas B. Kepler, Hua-Xin Liao, Barton F. Haynes

Abstract

Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their relationship to commensal bacteria. The dominant ileum B cell response was to Env gp41. Remarkably, a majority (82%) of the ileum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 antigen polyreactivity. Pyrosequencing revealed shared HIV-1 antibody clonal lineages between ileum and blood. Mutated immunoglobulin G antibodies cross-reactive with both Env gp41 and microbiota could also be isolated from the ileum of HIV-1 uninfected individuals. Thus, the gp41 commensal bacterial antigen cross-reactive antibodies originate in the intestine, and the gp41 Env response in HIV-1 infection can be derived from a preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
United Kingdom 1 1%
South Africa 1 1%
Unknown 81 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 29%
Researcher 24 28%
Student > Master 12 14%
Student > Doctoral Student 6 7%
Professor > Associate Professor 4 5%
Other 11 13%
Unknown 5 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 43%
Immunology and Microbiology 16 18%
Medicine and Dentistry 14 16%
Biochemistry, Genetics and Molecular Biology 11 13%
Chemical Engineering 1 1%
Other 2 2%
Unknown 6 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2014.
All research outputs
#218,431
of 12,015,871 outputs
Outputs from Cell Host & Microbe (Science Direct)
#161
of 1,470 outputs
Outputs of similar age
#4,478
of 201,126 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#3
of 48 outputs
Altmetric has tracked 12,015,871 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.