| Title |
HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), August 2014
|
| DOI | 10.1016/j.chom.2014.07.003 |
| Pubmed ID | |
| Authors |
Ashley M. Trama, M. Anthony Moody, S. Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, Christina Stolarchuk, Richard Scearce, Andrew Foulger, Dawn J. Marshall, John F. Whitesides, Thomas L. Jeffries, Kevin Wiehe, Lynn Morris, Bronwen Lambson, Kelly Soderberg, Kwan-Ki Hwang, Georgia D. Tomaras, Nathan Vandergrift, Katherine J.L. Jackson, Krishna M. Roskin, Scott D. Boyd, Thomas B. Kepler, Hua-Xin Liao, Barton F. Haynes |
| Abstract |
Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their relationship to commensal bacteria. The dominant ileum B cell response was to Env gp41. Remarkably, a majority (82%) of the ileum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 antigen polyreactivity. Pyrosequencing revealed shared HIV-1 antibody clonal lineages between ileum and blood. Mutated immunoglobulin G antibodies cross-reactive with both Env gp41 and microbiota could also be isolated from the ileum of HIV-1 uninfected individuals. Thus, the gp41 commensal bacterial antigen cross-reactive antibodies originate in the intestine, and the gp41 Env response in HIV-1 infection can be derived from a preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 17% |
| United States | 1 | 17% |
| Australia | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 1 | <1% |
| Unknown | 110 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 26% |
| Researcher | 28 | 24% |
| Student > Master | 14 | 12% |
| Student > Doctoral Student | 7 | 6% |
| Professor > Associate Professor | 6 | 5% |
| Other | 11 | 10% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 32% |
| Immunology and Microbiology | 22 | 19% |
| Medicine and Dentistry | 16 | 14% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Chemistry | 3 | 3% |
| Other | 4 | 3% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2021.
All research outputs
#702,574
of 25,654,806 outputs
Outputs from Cell Host & Microbe (Science Direct)
#512
of 2,646 outputs
Outputs of similar age
#6,514
of 240,709 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#4
of 39 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.