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Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

Overview of attention for article published in Cell, July 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
57 news outlets
blogs
1 blog
twitter
31 tweeters
facebook
4 Facebook pages
googleplus
1 Google+ user
reddit
2 Redditors

Citations

dimensions_citation
142 Dimensions

Readers on

mendeley
293 Mendeley
Title
Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man
Published in
Cell, July 2014
DOI 10.1016/j.cell.2014.04.043
Pubmed ID
Authors

Alexander Jais, Elisa Einwallner, Omar Sharif, Klaus Gossens, Tess Tsai-Hsiu Lu, Selma M. Soyal, David Medgyesi, Daniel Neureiter, Jamile Paier-Pourani, Kevin Dalgaard, J. Catharina Duvigneau, Josefine Lindroos-Christensen, Thea-Christin Zapf, Sabine Amann, Simona Saluzzo, Florian Jantscher, Patricia Stiedl, Jelena Todoric, Rui Martins, Hannes Oberkofler, Simone Müller, Cornelia Hauser-Kronberger, Lukas Kenner, Emilio Casanova, Hedwig Sutterlüty-Fall, Martin Bilban, Karl Miller, Andrey V. Kozlov, Franz Krempler, Sylvia Knapp, Carey N. Lumeng, Wolfgang Patsch, Oswald Wagner, J. Andrew Pospisilik, Harald Esterbauer

Abstract

Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the two conditions do not always coincide and the molecular determinants of "healthy" versus "unhealthy" obesity remain ill-defined. Chronic metabolic inflammation (metaflammation) is believed to be pivotal. Here, we tested a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic disease. Surprisingly, in matched biopsies from "healthy" versus insulin-resistant obese subjects we find HO-1 to be among the strongest positive predictors of metabolic disease in humans. We find that hepatocyte and macrophage conditional HO-1 deletion in mice evokes resistance to diet-induced insulin resistance and inflammation, dramatically reducing secondary disease such as steatosis and liver toxicity. Intriguingly, cellular assays show that HO-1 defines prestimulation thresholds for inflammatory skewing and NF-κB amplification in macrophages and for insulin signaling in hepatocytes. These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 5 2%
United Kingdom 3 1%
United States 3 1%
Mexico 2 <1%
Denmark 2 <1%
Spain 1 <1%
Brazil 1 <1%
Norway 1 <1%
Portugal 1 <1%
Other 4 1%
Unknown 270 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 68 23%
Researcher 65 22%
Student > Master 32 11%
Student > Bachelor 22 8%
Unspecified 21 7%
Other 85 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 115 39%
Medicine and Dentistry 63 22%
Biochemistry, Genetics and Molecular Biology 45 15%
Unspecified 31 11%
Immunology and Microbiology 12 4%
Other 27 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 457. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2019.
All research outputs
#20,288
of 13,727,890 outputs
Outputs from Cell
#138
of 14,775 outputs
Outputs of similar age
#261
of 187,956 outputs
Outputs of similar age from Cell
#5
of 159 outputs
Altmetric has tracked 13,727,890 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,775 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,956 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.