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A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization

Overview of attention for article published in Cell, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

1 news outlet
1 blog
1 tweeter


54 Dimensions

Readers on

109 Mendeley
A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization
Published in
Cell, August 2013
DOI 10.1016/j.cell.2013.07.001
Pubmed ID

Joo Min Park, Jia-Hua Hu, Aleksandr Milshteyn, Ping-Wu Zhang, Chester G. Moore, Sungjin Park, Michael C. Datko, Racquel D. Domingo, Cindy M. Reyes, Xiaodong J. Wang, Felicia A. Etzkorn, Bo Xiao, Karen K. Szumlinski, Dorothee Kern, David J. Linden, Paul F. Worley


Synaptic plasticity induced by cocaine and other drugs underlies addiction. Here we elucidate molecular events at synapses that cause this plasticity and the resulting behavioral response to cocaine in mice. In response to D1-dopamine-receptor signaling that is induced by drug administration, the glutamate-receptor protein metabotropic glutamate receptor 5 (mGluR5) is phosphorylated by microtubule-associated protein kinase (MAPK), which we show potentiates Pin1-mediated prolyl-isomerization of mGluR5 in instances where the product of an activity-dependent gene, Homer1a, is present to enable Pin1-mGluR5 interaction. These biochemical events potentiate N-methyl-D-aspartate receptor (NMDAR)-mediated currents that underlie synaptic plasticity and cocaine-evoked motor sensitization as tested in mice with relevant mutations. The findings elucidate how a coincidence of signals from the nucleus and the synapse can render mGluR5 accessible to activation with consequences for drug-induced dopamine responses and point to depotentiation at corticostriatal synapses as a possible therapeutic target for treating addiction.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Unknown 107 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 23%
Researcher 21 19%
Professor 10 9%
Student > Bachelor 8 7%
Student > Master 7 6%
Other 19 17%
Unknown 19 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 28%
Neuroscience 29 27%
Biochemistry, Genetics and Molecular Biology 8 7%
Medicine and Dentistry 8 7%
Chemistry 2 2%
Other 13 12%
Unknown 19 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2013.
All research outputs
of 13,387,082 outputs
Outputs from Cell
of 14,671 outputs
Outputs of similar age
of 155,343 outputs
Outputs of similar age from Cell
of 161 outputs
Altmetric has tracked 13,387,082 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,671 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,343 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.