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Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic

Overview of attention for article published in Cell, November 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 9,132)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Readers on

mendeley
127 Mendeley
citeulike
4 CiteULike
Title
Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic
Published in
Cell, November 2016
DOI 10.1016/j.cell.2016.10.014
Pubmed ID
Authors

William E. Diehl, Aaron E. Lin, Nathan D. Grubaugh, Luiz Max Carvalho, Kyusik Kim, Pyae Phyo Kyawe, Sean M. McCauley, Elisa Donnard, Alper Kucukural, Patrick McDonel, Stephen F. Schaffner, Manuel Garber, Andrew Rambaut, Kristian G. Andersen, Pardis C. Sabeti, Jeremy Luban, Diehl, William E, Lin, Aaron E, Grubaugh, Nathan D, Carvalho, Luiz Max, Kim, Kyusik, Kyawe, Pyae Phyo, McCauley, Sean M, Donnard, Elisa, Kucukural, Alper, McDonel, Patrick, Schaffner, Stephen F, Garber, Manuel, Rambaut, Andrew, Andersen, Kristian G, Sabeti, Pardis C, Luban, Jeremy, William E. Diehl, Aaron E. Lin, Nathan D. Grubaugh, Luiz Max Carvalho, Pyae Phyo Kyawe, Sean M. McCauley, Stephen F. Schaffner, Kristian G. Andersen, Pardis C. Sabeti

Abstract

The magnitude of the 2013-2016 Ebola virus disease (EVD) epidemic enabled an unprecedented number of viral mutations to occur over successive human-to-human transmission events, increasing the probability that adaptation to the human host occurred during the outbreak. We investigated one nonsynonymous mutation, Ebola virus (EBOV) glycoprotein (GP) mutant A82V, for its effect on viral infectivity. This mutation, located at the NPC1-binding site on EBOV GP, occurred early in the 2013-2016 outbreak and rose to high frequency. We found that GP-A82V had heightened ability to infect primate cells, including human dendritic cells. The increased infectivity was restricted to cells that have primate-specific NPC1 sequences at the EBOV interface, suggesting that this mutation was indeed an adaptation to the human host. GP-A82V was associated with increased mortality, consistent with the hypothesis that the heightened intrinsic infectivity of GP-A82V contributed to disease severity during the EVD epidemic.

Twitter Demographics

The data shown below were collected from the profiles of 100 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 4%
United Kingdom 3 2%
Japan 2 2%
Spain 1 <1%
France 1 <1%
Kenya 1 <1%
Brazil 1 <1%
Turkey 1 <1%
Netherlands 1 <1%
Other 1 <1%
Unknown 110 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 24%
Student > Ph. D. Student 29 23%
Student > Bachelor 22 17%
Student > Master 17 13%
Student > Doctoral Student 8 6%
Other 20 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 37%
Biochemistry, Genetics and Molecular Biology 28 22%
Immunology and Microbiology 22 17%
Medicine and Dentistry 16 13%
Veterinary Science and Veterinary Medicine 6 5%
Other 8 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 858. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#2,491
of 8,213,437 outputs
Outputs from Cell
#20
of 9,132 outputs
Outputs of similar age
#254
of 241,161 outputs
Outputs of similar age from Cell
#3
of 173 outputs
Altmetric has tracked 8,213,437 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 173 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.